Type-II hypersensitivity reactions

The hallmark of type-II hypersensitivity reaction is the antibody-mediated destruction of cells. One of the commonest type-II reactions occur during blood transfusion reactions. During blood transfusion reactions, host antibodies react with foreign antigens expressed by incompatible transfused blood cells and cause the destruction of these cells.  IgM and IgG antibody subtypes bind to cell surface […]

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Understanding type-1 hypersensitivity reactions II

Primary (preformed) mediators produce relatively short-lived biological effects Mast cells degranulation results in inflammatory reaction. Preformed mediators are mediators mast cells and basophils synthesize and store at all times. In other words, preformed mediators are always present in cytoplasmic granules of mast cells and basophils. Upon allergen stimulation, the first set of chemical mediators mast […]

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Understanding type-1 hypersensitivity reaction

Introduction The ability of our immune system to respond to, and attack potential harmful foreign agents is very important. Perhaps, even more important is the ability to recognize and attack potential harmful foreign substances while ignoring other foreign substances. Note that the emphasis here is ‘potential harmful foreign substances’ and not just any foreign substance. […]

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